王桂荣课题组
姓名: |
王桂荣 |
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职称: |
研究员,博士生导师,国家杰出青年科学基金获得者,国务院特殊津贴专家,国家有突出贡献中青年专家,入选中组部领军人才、人社部国家百千万人才工程、科技部创新人才推进计划 |
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电话/传真: |
0755-23250160 |
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电子邮件: |
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实验室主页: |
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研究方向: |
昆虫化学生态学、昆虫与植物互作、农业害虫功能基因组学 |
简历介绍:
王桂荣,研究员,博士生导师,国家杰出青年科学基金获得者,国务院特殊津贴专家,国家有突出贡献中青年专家,入选中组部领军人才、人社部国家百千万人才工程、科技部创新人才推进计划。
2002年毕业于中国农业科学院农业昆虫与害虫防治专业,获农学博士学位。2005年-2010年美国范德比尔特大学从事博士后研究。长期从事害虫化学生态学和功能基因组学的研究工作,提出以嗅觉受体为靶标高通量筛选昆虫行为调控剂的新思路,研发了重要农业害虫绿色防控新技术。主持国家自然科学基金杰出青年基金、国家基金重点项目、国家基金重点国际合作项目、国家重点研发计划等项目。发表研究论文150余篇,其中以第一或者通讯作者在PNAS、Current Biology、Mole.Biol.Evol.、eLife等杂志上发表SCI论文80余篇,获授权国家发明专利8件,主(参)编著作3 部。
工作经历:
2019.5-至今 中国农业科学院(深圳)农业基因组研究所 研究员,博士生导师
2011.1-至今 中国农业科学院植物保护研究所 研究员,博士生导师
2005.1-2010.12 中国农业科学院植物保护研究所 副研究员,硕士生导师
2005.3-2010.10 美国Vanderbilt大学 Senior/Research Associate
2002.9-2005.1 中国农业科学院植物保护研究所 助理研究员
2002.7-2002.9 中国农业科学院植物保护研究所 实习期
教育经历:
1999.9-2002.7 中国农业科学院研究生院 获博士学位
1996.9-1999.7 中国农业科学院研究生院 获硕士学位
1992.9-1996.7 安徽师范大学生物系 大学本科
研究领域:
研究方向:
实验室的主要研究方向是昆虫化学生态学和功能基因组学。目前的研究课题是:(1)昆虫的化学生态学机制和昆虫行为调节剂的开发。这是为了利用组学、神经生物学和结构生物学对关键的化学传感分子靶标进行功能表征,阐明昆虫嗅觉行为的机制,然后利用人工智能和高通量筛选开发新的昆虫行为调节剂。(2) 昆虫RNAi的分子机制及其应用。研究不同昆虫,特别是鞘翅目、鳞翅目和直翅目重要害虫RNAi差异的分子机制。同时,我们利用功能基因组学、合成生物学和纳米材料等新技术开发RNAi农药。
研究进展:
深圳市科技计划:该项目由深圳市科创委立项。该基金会的目的是通过功能基因组学开发新技术,以环保的方式控制害虫。
(1) 对害虫基因组进行高质量测序和组装。
(2) 识别害虫特定生物过程中的关键基因,如嗅觉行为或表型,作为分子靶标。
(3) 开发基于目标的害虫防治技术,如昆虫行为调节剂或RNAi杀虫剂。
代表论著:
代表论文:
1. Bing Wang, Wanying Dong, Huimin Li, Chiara D’Onofrio, Penghua Bai, Ruipeng Chen, Lulu Yang, Jinan Wu, Xiaoqing Wang, Bo Wang, Dong Ai, Wolfgang Knoll, Paolo Pelosi *, Guirong Wang*. Molecular basis of (E)-b-farnesene-mediated aphid location in the predator Eupeodes corolla. Current Biology 2022, 32, 951–962.
2. Wang C, Zhang S, Guo MB, Hou XQ, Yang B, Wang GR*. Optimization of a pheromone lure by analyzing the peripheral coding of sex pheromones of Spodoptera frugiperda in China. Pest Manag Sci. 2022 Jul;78(7):2995-3004.
3. Mengbo Guo#, Lixiao Du#, Qiuyan Chen, Yilu Feng, Jin Zhang, Xiaxuan Zhang, Ke Tian, Song Cao, Tianyu Huang, Emmanuelle Jacquin-Joly, Guirong Wang*, Yang Liu*. Odorant receptors for detecting flowering plant cues are functionally conserved across moths and butterflies. Molecular Biology and Evolution. 2021, 38(4): 1413-1427
4. Sai Zhang#, Shuwei Yan#, Zhixiang Zhang, Song Cao, Bin Li, Yang Liu*, Guirong Wang*. Identification and functional characterization of sex pheromone receptors in mirid bugs (Heteroptera: Miridae). Insect Biochemistry and Molecular Biology. 2021, 136: 103621.
5. Song Cao#, Yang Liu#, Bing Wang, Guirong Wang*. A single point mutation causes one-way alteration of pheromone receptor function in two Heliothis species. iScience. 2021, 24: 102981.
6. Shuai Liu, Hetan Chang, Wei Liu, Weichan Cui, Yang Liu, Yinliang Wang, Bingzhong Ren*, Guirong Wang*. Essential role for SNMP1 in the detection of sex pheromone components in Helicoverpa armigera. Insect Biochemistry and Molecular Biology. 2020, 127: 103485.
7. Yang Liu#, Hangwei Liu#, Hengchao Wang#, Tianyu Huang#, Bo Liu, Bin Yang, Lijuan Yin, Bin Li, Yan Zhang, Sai Zhang, Fan Jiang, Xiaxuan Zhang, Yuwei Ren, Bing Wang, Sen Wang, Yanhui Lu, Kongming Wu*, Wei Fan*, Guirong Wang*. Apolygus lucorum genome provides insights into omnivorousness and mesophyll feeding. Molecular Ecology Resources, 2021, 21: 287-300.
8. Lucie Bastin-Heline, Arthur de Fouchier, Song Cao, Fotini Koutroumpa, Gabriela Caballero-Vidal, Stefania Robakiewicz, Christelle Monsempes, Marie-Christine Francois, Tatiana Ribeyre, Annick Maria, Thomas Chertemps, Anne de Cian, William B Walker III, Guirong Wang*, Emmanuelle Jacquin-Joly*, Nicolas Montagne*. A novel lineage of candidate pheromone receptors for sex communication in moths. elife. 2019, 8: e49826.
9. Paolo Pelosi, Immacolata Iovinella, Jiao Zhu, Guirong Wang*, Francesca Romana Dani*. Beyond chemoreception: different tasks of soluble olfactory proteins in insects. Biological Reviews. 2018, 93: 184-200
10. Hetan Chang, Yang Liu, Dong Ai, Xingchuan Jiang, Shuanglin Dong, Guirong Wang*. A pheromone antagonist regulates optimal mating time in the moth, Helicoverpa armigera. Current Biology, 2017, 27(11): 1610-1615
11. R Zhang, B Wang, G Grossi, P Falabella, Y Liu, S Yan, J Lu, J Xi, G Wang*. Molecular Basis of Alarm Pheromone Detection in Aphids. Current Biology. 2017, 27(1):55-61
12. Zhu J, S Arena, S Spinelli, D Liu, G Zhang, R Wei, C Cambillau, A Scaloni, G Wang*, P Pelosi*. Reverse Chemical ecology: Olfactory proteins from the giant panda and their interactions with putative pheromones and bamboo volatiles. PNAS, 2017, 114(46): E9802-E9810.
13. Paolo Pelosi, Immacolata Iovinella, Jiao Zhu, Guirong Wang*, Francesca Romana Dani*. Beyond chemoreception: different tasks of soluble olfactory proteins in insects. Biology Reviews. 2017. doi: 10.1111/brv.12339.
14. Bing Wang, Yang Liu * and Gui-Rong Wang*. Chemosensory genes in the antennaltranscriptome of two syrphid species,Episyrphusbalteatus and Eupeodes corolla(Diptera: Syrphidae). BMC Genomics (2017) 18:586
15. Jiao Zhu, Liping Ban, Li-Mei Song, Yang Liu, Paolo Pelosi*, Guirong Wang*. General Odorant-Binding Proteins and sex pheromone guide larvae of Plutella xylostella to better food. Insect Biochemistry and Molecular Biology. 2016, 72:10-19.
16. J Zhu, I Iovinella, F Romana Dani, Y Liu, L Huang, Y Liu, C Wang, P Pelosi*, G Wang*. Conserved chemosensory proteins in the proboscis and eyes of Lepidoptera.IJBS, 2016 12(11): 1394-1404
17. J Wei, T Fu, D Cao, T Yang, Y Liu, G Wang*. A TRPA1 channel that senses thermal stimulus and irritating chemicals in Helicoverpaarmigera. Insect Molecular Biology. 2015, 24(4): 412-421.
18. Jin Zhang, Shuwei Yan, Yang Liu, Emmanuelle Jacquin-Joly, Shuanglin Dong, Guirong Wang*. Identification and Functional Characterization of Sex Pheromone Receptors in the Common Cutworm (Spodoptera litura). Chemical Senses. 2015, 40(1):7-16.
19. Liu C, Liu Y, Walker WB, Dong SL*, Wang GR*. Identification and functional characterization of sex pheromone receptors in beet armyworm Spodoptera exigua (Hübner). Insect Biochemistry and Molecular Biology. 2013, 43: 747-754
20. Wang GR, Allison Carey, John R. Carlson and Laurence J. Zwiebel. The Molecular Basis of Odor Coding in Malaria Vector Mosquito Anopheles gambiae. PNAS 2010, 107(9):4418-23
21. Allison Carey, Guirong Wang, Chih-Ying Su, Laurence J. Zwiebel, and John R. Carlson. Odorant reception in the malaria mosquito Anopheles gambiae. Nature 2010 464(7285):66-71.
22. Wang GR, Y.T. Qiu, T. Lu, H. Kwon, R. J. Pitts, J.J. van Loon, W. Takken and L.J. Zwiebel. Anopheles gambiae TRPA1 is a heat-activated channel expressed in thermosensitive sensilla of female antennae. European Journal of Neuroscience. 2009, 30: 967-974.
23. Y.F. Xia, Wang GR (first co-author), D Buscariollo, R.J. Pitts, H. Wegner and L.J. Zwiebel. The Molecular and Cellular Basis of Olfactory Behavior in Anopheles gambiae Larvae. PNAS. 2008, 105(17):6433-8.
24. T. Lu, YT. Qiu, Wang GR (first co-author), J.Y. Young, M. Rutzler, H.W. Kwon, R. J. Pitts, J. J.A. van Loon, J. R. Carlson, W. Takken, and L. J. Zwiebel. Odor Coding in the Maxillary Palp of the Malaria Vector Mosquito Anopheles gambiae. Current Biology. 2007, 17(18): 1533-1544.
代表专利:
1. 王桂荣,王婵,刘杨,杨斌,一种基于草地贪夜蛾性信息素的高效引诱剂及其应用,中国:ZL202111509744.2
2. 王桂荣,杨斌,绿盲蝽decapentaplegic基因及其RNAi在害虫防控中的应用,中国:ZL201810716459.X
3. 王桂荣,�:靥�,刘杨,艾东,鉴定一种物质对昆虫行为是否有影响及有何种影响的方法,中国:ZL201710195931.5
4. 王桂荣,李峰奇,杨婷,刘杨,一种与萜烯类化合物合成相关的蛋白及其应用,中国:ZL201610078482.1
5. 王桂荣,李峰奇,杨婷,刘杨,一种与E-b-石竹烯和E-a-律草烯合成相关的蛋白及其应用,中国:ZL 2016 1 0077850.0
王桂荣课题组更新于2023年11月